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KMID : 0644120140270010152
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Journal of Oriental Gynecology
2014 Volume.27 No. 1 p.152 ~ p.166
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Review of Experimental Studies on Antithrombotic in Oriental Medicine -Within Articles in The Journal of Oriental Obstetrics & Gynecology Since 2001’-
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Jung Soo-Jung
Ma Young-Hun
Choi Seung-Bum
Park Kyung-Mi
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Abstract
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Purpose: The purpose of this study is to compare with the result of experimental study about antithrombotic effect by reviewing recent oriental medicine journals that have been published since 2001‘ in Korea.
Methods: Articles on antithrombotic effect that have been published from 2001’ to 2013’ in oriental medicine journals registered National Research Foundation of Korea were searched. After that, 12 articles using same ‘thrombosis condition model’ were selected and reviewed.
Results: The results were as follows.
1. If there is no limit drug concentrations, platelet aggregation induced by adenosine diphosphate (ADP) in hyulbuchukeo-tanggamibang (HBCT) was the largest aggregation inhibitory effect and platelet aggregation induced by epinephrine in Saegeum-san (SGS), Jogan-tanggagambang (JGTG), hyulbuchukeo-tanggamibang (HBCT) had a large inhibitory effect on aggregation.
2. At the lowest concentration, Mokdan-san (MDS) of the inhibition of platelet aggregation induced by ADP and Hyunhosaik-san (HHS) of the inhibition of platelet aggregation induced by epinephrine were effective.
3. Pulmonary embolism induced by collagen and epinephrine in Neungasojeok-tang (NSJT) has the highest antithrombotic effect.
4. Pathological conditions of extravasated blood by dextran, Jogan-tanggagambang (JGTG) has the highest inhibitory effect on decrease in platelet numbers. Compared to the rest of the experimental drug, Saegeum-san (SGS), Heanggyonghonghwa-tang (HGTHHT), Wusl-san (WSS), Mokdan-san (MDS) showed significant inhibitory effect on the prothrombin time (PT) increases. Honghwadanggui-san (HDS), Saegeum-san (SGS) showed significant inhibitory effect on increase in activated partial thromboplastin time (APTT) and Jogan-tanggagambang (JGTG), Heanggyonghonghwa-tang (HGTHHT) showed significant inhibitory effect on decrease in fibrinogen.
Conclusions: This result will provide useful information for the prescriptions of antithrombotic medicine in the field of Oriental medicine. We will have to carry out further studies that will compare each herb used in the diseases caused by extravasated blood.
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KEYWORD
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Antithrombotic, Oriental Medicine, Extravasated Blood
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